Ontology highlight
ABSTRACT:
SUBMITTER: Ohata S
PROVIDER: S-EPMC4126882 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Ohata Shinya S Nakatani Jin J Herranz-Pérez Vicente V Cheng JrGang J Belinson Haim H Inubushi Toshiro T Snider William D WD García-Verdugo Jose Manuel JM Wynshaw-Boris Anthony A Alvarez-Buylla Arturo A
Neuron 20140718 3
Defects in ependymal (E) cells, which line the ventricle and generate cerebrospinal fluid flow through ciliary beating, can cause hydrocephalus. Dishevelled genes (Dvls) are essential for Wnt signaling, and Dvl2 has been shown to localize to the rootlet of motile cilia. Using the hGFAP-Cre;Dvl1(-/-);2(flox/flox);3(+/-) mouse, we show that compound genetic ablation of Dvls causes hydrocephalus. In hGFAP-Cre;Dvl1(-/-);2(flox/flox);3(+/-) mutants, E cells differentiated normally, but the intracellu ...[more]