Biphasic effect of melanocortin agonists on metabolic rate and body temperature.
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ABSTRACT:
SUBMITTER: Lute B
PROVIDER: S-EPMC4126889 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Biphasic effect of melanocortin agonists on metabolic rate and body temperature.
Lute Beth B Jou William W Lateef Dalya M DM Goldgof Margalit M Xiao Cuiying C Piñol Ramón A RA Kravitz Alexxai V AV Miller Nicole R NR Huang Yuning George YG Girardet Clemence C Butler Andrew A AA Gavrilova Oksana O Reitman Marc L ML
Cell metabolism 20140626 2
The melanocortin system regulates metabolic homeostasis and inflammation. Melanocortin agonists have contradictorily been reported to both increase and decrease metabolic rate and body temperature. We find two distinct physiologic responses occurring at similar doses. Intraperitoneal administration of the nonselective melanocortin agonist MTII causes a melanocortin-4 receptor (Mc4r)-mediated hypermetabolism/hyperthermia. This is preceded by a profound, transient hypometabolism/hypothermia that i ...[more]
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