Ontology highlight
ABSTRACT:
SUBMITTER: van Berlo JH
PROVIDER: S-EPMC4127035 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
van Berlo Jop H JH Kanisicak Onur O Maillet Marjorie M Vagnozzi Ronald J RJ Karch Jason J Lin Suh-Chin J SC Middleton Ryan C RC Marbán Eduardo E Molkentin Jeffery D JD
Nature 20140507 7500
If and how the heart regenerates after an injury event is highly debated. c-kit-expressing cardiac progenitor cells have been reported as the primary source for generation of new myocardium after injury. Here we generated two genetic approaches in mice to examine whether endogenous c-kit(+) cells contribute differentiated cardiomyocytes to the heart during development, with ageing or after injury in adulthood. A complementary DNA encoding either Cre recombinase or a tamoxifen-inducible MerCreMer ...[more]