Ontology highlight
ABSTRACT:
SUBMITTER: Zhou BO
PROVIDER: S-EPMC4127103 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Zhou Bo O BO Yue Rui R Murphy Malea M MM Peyer James G JG Morrison Sean J SJ
Cell stem cell 20140619 2
Studies of the identity and physiological function of mesenchymal stromal cells (MSCs) have been hampered by a lack of markers that permit both prospective identification and fate mapping in vivo. We found that Leptin Receptor (LepR) is a marker that highly enriches bone marrow MSCs. Approximately 0.3% of bone marrow cells were LepR(+), 10% of which were CFU-Fs, accounting for 94% of bone marrow CFU-Fs. LepR(+) cells formed bone, cartilage, and adipocytes in culture and upon transplantation in v ...[more]