The functional pitch of an organ: quantification of tissue texture with photoacoustic spectrum analysis.

ABSTRACT:

Purpose

To investigate the use of photoacoustic (PA) spectrum analysis (PASA) to identify microstructural changes corresponding to fat accumulation in mouse livers ex vivo and in situ.

Materials and methods

The laboratory animal protocol for this work was approved by the university committee on use and care of animals. Six mice with normal livers and six mice with fatty livers were examined ex vivo with a PA system at 1200 nm, and nine similar pairs of mice were examined at 532 nm. To explore the feasibility of this technique for future study in an in vivo mouse model, an additional pair of normal and fatty mouse livers was scanned in situ with an ultrasonographic (US) and PA dual-modality imaging system. The PA signals acquired were analyzed by using the proposed PASA metho

SUBMITTER: Xu G 

PROVIDER: S-EPMC4127893 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature