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The EMT (epithelial-mesenchymal-transition)-related protein expression indicates the metastatic status and prognosis in patients with ovarian cancer.


ABSTRACT: The epithelial-mesenchymal-transition (EMT) is an important step in the invasion and metastasis of cancer. A critical molecular feature of this process is the downregulation of the E-cadherin expression, which is primarily controlled by Snail-related zinc-finger transcription factors. The aim of this study was to evaluate the prognostic impact of the expression of EMT-related proteins (E-cadherin and Snail) in patients with ovarian cancer.An immunohistochemical analysis was conducted using tissue microarray samples of 174 primary tumors and 34 metastases of ovarian carcinoma, and the relationships between the protein expression, clinicopathological features and outcomes were investigated.A reduced E-cadherin expression was observed in 36.8% of the primary tumors and 30.4%, 35.7%, 37.7% and 52.7% of the stage I, II, III and IV tumors, respectively. The nuclear expression of Snail was positive in 33.9% of the primary tumors. The rate of an EMT-positive status, as represented by both a reduced E-cadherin expression and a nuclear expression of Snail, was significantly higher in the patients with peritoneal dissemination than in those without (p?

SUBMITTER: Takai M 

PROVIDER: S-EPMC4127950 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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The EMT (epithelial-mesenchymal-transition)-related protein expression indicates the metastatic status and prognosis in patients with ovarian cancer.

Takai Masaaki M   Terai Yoshito Y   Kawaguchi Hiroshi H   Ashihara Keisuke K   Fujiwara Satoe S   Tanaka Tomohito T   Tsunetoh Satoshi S   Tanaka Yoshimichi Y   Sasaki Hiroshi H   Kanemura Masanori M   Tanabe Akiko A   Ohmichi Masahide M  

Journal of ovarian research 20140727


<h4>Objectives</h4>The epithelial-mesenchymal-transition (EMT) is an important step in the invasion and metastasis of cancer. A critical molecular feature of this process is the downregulation of the E-cadherin expression, which is primarily controlled by Snail-related zinc-finger transcription factors. The aim of this study was to evaluate the prognostic impact of the expression of EMT-related proteins (E-cadherin and Snail) in patients with ovarian cancer.<h4>Methods</h4>An immunohistochemical  ...[more]

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