Retinal regeneration in adult zebrafish requires regulation of TGF? signaling.
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ABSTRACT:
SUBMITTER: Lenkowski JR
PROVIDER: S-EPMC4127981 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Retinal regeneration in adult zebrafish requires regulation of TGFβ signaling.
Lenkowski Jenny R JR Qin Zhao Z Sifuentes Christopher J CJ Thummel Ryan R Soto Celina M CM Moens Cecilia B CB Raymond Pamela A PA
Glia 20130805 10
Müller glia are the resident radial glia in the vertebrate retina. The response of mammalian Müller glia to retinal damage often results in a glial scar and no functional replacement of lost neurons. Adult zebrafish Müller glia, in contrast, are considered tissue-specific stem cells that can self-renew and generate neurogenic progenitors to regenerate all retinal neurons after damage. Here, we demonstrate that regulation of TGFβ signaling by the corepressors Tgif1 and Six3b is critical for the p ...[more]
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