Ontology highlight
ABSTRACT:
SUBMITTER: Gaughan A
PROVIDER: S-EPMC4128005 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Gaughan A A Wang J J Pelletier R P RP Nadasdy T T Brodsky S S Roy S S Lodder M M Bobek D D Mofatt-Bruce S S Fairchild R L RL Henry M L ML Hadley G A GA
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20140110 2
We utilized mouse models to elucidate the immunologic mechanisms of functional graft loss during mixed antibody-mediated rejection of renal allografts (mixed AMR), in which humoral and cellular responses to the graft occur concomitantly. Although the majority of T cells in the graft at the time of rejection were CD8 T cells with only a minor population of CD4 T cells, depletion of CD4 but not CD8 cells prevented acute graft loss during mixed AMR. CD4 depletion eliminated antidonor alloantibodies ...[more]