Ontology highlight
ABSTRACT:
SUBMITTER: Carr SM
PROVIDER: S-EPMC4128150 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Carr Simon M SM Munro Shonagh S Zalmas Lykourgos-Panagiotis LP Fedorov Oleg O Johansson Catrine C Krojer Tobias T Sagum Cari A CA Bedford Mark T MT Oppermann Udo U La Thangue Nicholas B NB
Proceedings of the National Academy of Sciences of the United States of America 20140721 31
The retinoblastoma tumor suppressor protein pRb is a key regulator of cell cycle progression and mediator of the DNA damage response. Lysine methylation at K810, which occurs within a critical Cdk phosphorylation motif, holds pRb in the hypophosphorylated growth-suppressing state. We show here that methyl K810 is read by the tandem tudor domain containing tumor protein p53 binding protein 1 (53BP1). Structural elucidation of 53BP1 in complex with a methylated K810 pRb peptide emphasized the role ...[more]