Analysis of differential miRNA expression in primary tumor and stroma of colorectal cancer patients.
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ABSTRACT:
SUBMITTER: Della Vittoria Scarpati G
PROVIDER: S-EPMC4128171 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
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Analysis of differential miRNA expression in primary tumor and stroma of colorectal cancer patients.
Della Vittoria Scarpati Giuseppina G Calura Enrica E Di Marino Mariacristina M Romualdi Chiara C Beltrame Luca L Malapelle Umberto U Troncone Giancarlo G De Stefano Alfonso A Pepe Stefano S De Placido Sabino S D'Incalci Maurizio M Marchini Sergio S Carlomagno Chiara C
BioMed research international 20140710
Microarray technology was used to profile miRNA expression in primary tumor and stromal tissue from paraffin embedded material of 51 patients with colorectal cancer. 26 miRNAs resulted differentially expressed with at least 2-fold change in tumor tissue with respect to stroma (16 more expressed in the tumor and 10 more expressed in the stroma). 10/26 were confirmed as differentially expressed at qRTPCR: miR-200c-3p, miR-141-3p, miR-200b-3p, miR-200a-3p, miR-1246, miR-92a-3p, miR-194-5p, miR-192- ...[more]
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