Ontology highlight
ABSTRACT:
SUBMITTER: Santiago C
PROVIDER: S-EPMC4128229 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Santiago Celine C Labrador Juan-Pablo JP Bashaw Greg J GJ
Cell reports 20140327 1
Transcription factors establish neural diversity and wiring specificity; however, how they orchestrate changes in cell morphology remains poorly understood. The Drosophila Roundabout (Robo) receptors regulate connectivity in the CNS, but how their precise expression domains are established is unknown. Here, we show that the homeodomain transcription factor Hb9 acts upstream of Robo2 and Robo3 to regulate axon guidance in the Drosophila embryo. In ventrally projecting motor neurons, hb9 is requir ...[more]