Ontology highlight
ABSTRACT:
SUBMITTER: Rudolph MJ
PROVIDER: S-EPMC4128236 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Rudolph Michael J MJ Vance David J DJ Cheung Jonah J Franklin Matthew C MC Burshteyn Fiana F Cassidy Michael S MS Gary Ebony N EN Herrera Cristina C Shoemaker Charles B CB Mantis Nicholas J NJ
Journal of molecular biology 20140604 17
Ricin is a select agent toxin and a member of the RNA N-glycosidase family of medically important plant and bacterial ribosome-inactivating proteins. In this study, we determined X-ray crystal structures of the enzymatic subunit of ricin (RTA) in complex with the antigen binding domains (VHH) of five unique single-chain monoclonal antibodies that differ in their respective toxin-neutralizing activities. None of the VHHs made direct contact with residues involved in RTA's RNA N-glycosidase activi ...[more]