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Curcumin glucuronides: assessing the proliferative activity against human cell lines.

ABSTRACT: A gram scale synthesis of the glucuronide metabolites of curcumin were completed in four steps. The newly synthesized curcumin glucuronide compounds 2 and 3 along with curcumin 1 were tested and their anti-proliferative effects against KBM-5, Jurkat cell, U266, and A549 cell lines were reported. Biological data revealed that as much as 1 ?M curcumin 1 exhibited anticancer activity and almost 100% cell kill was noted at 10 ?M on two out of four cell lines; while curcumin mono-glucuronide 2 as well as di-glucuronide 3 displayed no suppression of cell proliferation.

SUBMITTER: Pal A

PROVIDER: S-EPMC4128398 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Curcumin glucuronides: assessing the proliferative activity against human cell lines.

Pal Ashutosh A Sung Bokyung B Bhanu Prasad Basvoju A BA Schuber Paul T PT Prasad Sahdeo S Aggarwal Bharat B BB Bornmann William G WG

Bioorganic & medicinal chemistry 20131112 1

A gram scale synthesis of the glucuronide metabolites of curcumin were completed in four steps. The newly synthesized curcumin glucuronide compounds 2 and 3 along with curcumin 1 were tested and their anti-proliferative effects against KBM-5, Jurkat cell, U266, and A549 cell lines were reported. Biological data revealed that as much as 1 μM curcumin 1 exhibited anticancer activity and almost 100% cell kill was noted at 10 μM on two out of four cell lines; while curcumin mono-glucuronide 2 as wel ...[more]

PMID: 24280069

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