Solution structure of a sponge-derived cystine knot peptide and its notable stability.
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ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC4128683 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Solution structure of a sponge-derived cystine knot peptide and its notable stability.
Li Huayue H Su Mingzhi M Hamann Mark T MT Bowling John J JJ Kim Hyung Sik HS Jung Jee H JH
Journal of natural products 20140205 2
A novel cystine knot peptide, asteropsin E (ASPE), was isolated from an Asteropus sp. marine sponge. The primary, secondary, and tertiary structures of ASPE were determined by high-resolution 2D NMR spectroscopy (900 MHz). With the exception of an N-terminal modification, ASPE shares properties with the previously reported asteropsins A-D, that is, the absence of basic residues, a highly acidic nature, conserved structurally important residues (including two cis-prolines), and a highly conserved ...[more]
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