Altered migratory behavior of interneurons in a model of cortical dysplasia: the influence of elevated GABAA activity.

ABSTRACT: Appropriate function of the neocortex depends on timely generation and migration of cells produced in the germinal zones of the neocortex and ganglionic eminence (GE). Failure to accurately complete migration results in cortical dysplasia, a developmental syndrome implicated in many neurologic disorders. We developed a model of cortical dysplasia in ferrets involving administration of methylaxozymethanol acetate (MAM), an antimitotic, to pregnant ferrets on gestational day 33, leading to dramatic reduction of layer 4 in the neocortex. Here, using time-lapse video imaging, we investigate dynamic behavior of migrating cells arising from the GE and cortical ventricular zone (CVZ) in ferrets and the role of GABAA activity. Treatment with MAM significantly reduced migration speed and the relati

SUBMITTER: Abbah J 

PROVIDER: S-EPMC4128700 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature