Ontology highlight
ABSTRACT:
SUBMITTER: Cernat L
PROVIDER: S-EPMC4128715 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Cernat Laura L Blaj Cristina C Jackstadt Rene R Brandl Lydia L Engel Jutta J Hermeking Heiko H Jung Andreas A Kirchner Thomas T Horst David D
PloS one 20140811 8
Colonic crypts are stereotypical structures with distinct stem cell, proliferating, and differentiating compartments. Colorectal cancers derive from colonic crypt epithelia but, in contrast, form morphologically disarrayed glands. In this study, we investigated to which extent colorectal cancers phenocopy colonic crypt architecture and thus preserve structural organization of the normal intestinal epithelium. A subset of colon cancers showed crypt-like compartments with high WNT activity and nuc ...[more]