Ontology highlight
ABSTRACT:
SUBMITTER: Jamain S
PROVIDER: S-EPMC4128749 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Jamain Stéphane S Cichon Sven S Etain Bruno B Mühleisen Thomas W TW Georgi Alexander A Zidane Nora N Chevallier Lucie L Deshommes Jasmine J Nicolas Aude A Henrion Annabelle A Degenhardt Franziska F Mattheisen Manuel M Priebe Lutz L Mathieu Flavie F Kahn Jean-Pierre JP Henry Chantal C Boland Anne A Zelenika Diana D Gut Ivo I Heath Simon S Lathrop Mark M Maier Wolfgang W Albus Margot M Rietschel Marcella M Schulze Thomas G TG McMahon Francis J FJ Kelsoe John R JR Hamshere Marian M Craddock Nicholas N Nöthen Markus M MM Bellivier Frank F Leboyer Marion M
PloS one 20140811 8
Bipolar disorder is one of the most common and devastating psychiatric disorders whose mechanisms remain largely unknown. Despite a strong genetic contribution demonstrated by twin and adoption studies, a polygenic background influences this multifactorial and heterogeneous psychiatric disorder. To identify susceptibility genes on a severe and more familial sub-form of the disease, we conducted a genome-wide association study focused on 211 patients of French origin with an early age at onset an ...[more]