Managing Sjogren's Syndrome and non-Sjogren Syndrome dry eye with anti-inflammatory therapy.
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ABSTRACT:
SUBMITTER: Coursey TG
PROVIDER: S-EPMC4128848 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Managing Sjögren's Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy.
Coursey Terry G TG de Paiva Cintia S CS
Clinical ophthalmology (Auckland, N.Z.) 20140804
Dry eye from Sjögren's syndrome is a multifactorial disease that results in dysfunction of the lacrimal functional unit. Studies have shown changes in tear composition, including inflammatory cytokines, chemokines, and metalloproteinase. T-lymphocytes have been shown to increase in the conjunctiva and lacrimal glands in patient and animal models. This inflammation is in part responsible for the pathogenesis of the disease, which results in symptoms of eye irritation, ocular surface epithelial di ...[more]
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