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Update on Janus kinase antagonists in inflammatory bowel disease.

ABSTRACT: Janus kinase (JAK) inhibitors have emerged as a novel orally administered small-molecule therapy for the treatment of ulcerative colitis and possibly Crohn disease. These molecules are designed to selectively target the activity of specific JAKs and to offer a targeted mechanism of action without risk of immunogenicity. Based on data from clinical trials in rheumatoid arthritis and phase 2 studies in inflammatory bowel disease, tofacitinib and other JAK inhibitors are likely to become a new form of medical therapy for the treatment of inflammatory bowel disease.

SUBMITTER: Boland BS

PROVIDER: S-EPMC4129380 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Update on Janus kinase antagonists in inflammatory bowel disease.

Boland Brigid S BS Sandborn William J WJ Chang John T JT

Gastroenterology clinics of North America 20140624 3

Janus kinase (JAK) inhibitors have emerged as a novel orally administered small-molecule therapy for the treatment of ulcerative colitis and possibly Crohn disease. These molecules are designed to selectively target the activity of specific JAKs and to offer a targeted mechanism of action without risk of immunogenicity. Based on data from clinical trials in rheumatoid arthritis and phase 2 studies in inflammatory bowel disease, tofacitinib and other JAK inhibitors are likely to become a new form ...[more]

PMID: 25110261

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