Ontology highlight
ABSTRACT:
SUBMITTER: Boxer AL
PROVIDER: S-EPMC4129545 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Boxer Adam L AL Lang Anthony E AE Grossman Murray M Knopman David S DS Miller Bruce L BL Schneider Lon S LS Doody Rachelle S RS Lees Andrew A Golbe Lawrence I LI Williams David R DR Corvol Jean-Cristophe JC Ludolph Albert A Burn David D Lorenzl Stefan S Litvan Irene I Roberson Erik D ED Höglinger Günter U GU Koestler Mary M Jack Clifford R CR Van Deerlin Viviana V Randolph Christopher C Lobach Iryna V IV Heuer Hilary W HW Gozes Illana I Parker Lesley L Whitaker Steve S Hirman Joe J Stewart Alistair J AJ Gold Michael M Morimoto Bruce H BH
The Lancet. Neurology 20140527 7
<h4>Background</h4>In preclinical studies, davunetide promoted microtubule stability and reduced tau phosphorylation. Because progressive supranuclear palsy (PSP) is linked to tau pathology, davunetide could be a treatment for PSP. We assessed the safety and efficacy of davunetide in patients with PSP.<h4>Methods</h4>In a double-blind, parallel group, phase 2/3 trial, participants were randomly assigned with permuted blocks in a 1:1 ratio to davunetide (30 mg twice daily, intranasally) or placeb ...[more]