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TRAF6 polymorphisms not associated with the susceptibility to and severity of sepsis in a Chinese population.

ABSTRACT: BACKGROUND:The tumor necrosis factor recepter associated factor (TRAF) 6 is an important intracellular adapter protein that plays a pivotal role in activating multiple inflammatory and immune related processes induced by cytokines. TRAF6 represents a strong candidate susceptibility factor for sepsis. We investigated whether polymorphisms at the TRAF6 gene are associated with the susceptibility to and severity of sepsis. METHODS:A hospital-based case-control study was conducted with 255 patients with sepsis and 260 controls who were recruited from Zhengzhou, China. Haplotype tagging single nucleotide polymorphisms (htSNPs) were selected from the HapMap database and genotyped using the SNPstream genotyping platform. The associations with the susceptibility and disease severity of sepsis were estimated by logistic regression, and adjusted for age, sex, smoking, drinking, chronic diseases status, APACHEII score and critical illness status. RESULTS:A total of 13 TRAF6 SNPs were tagged by 7 htSNPs. Five htSNPs (rs5030490, rs5030411, rs5030416, rs5030445 and rs3740961) were genotyped in the case control study. Genotype frequencies of the htSNPs were conformed to the Hardy-Weinberg equilibrium in both patients and controls. No significant association was found between the 5 htSNPs and the susceptibility to and severity of sepsis. Compared with the main haplotype -11120A/-10688T/-9423A/805G/12967G, no certain haplotype was associated with the significantly susceptibility to or severity of sepsis. CONCLUSION:TRAF6 gene polymorphisms might not play a major role in mediating the susceptibility to and severity of sepsis in the Chinese population. A larger population-based case-control study is warranted.

SUBMITTER: Fang Y

PROVIDER: S-EPMC4129682 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature

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TRAF6 polymorphisms not associated with the susceptibility to and severity of sepsis in a Chinese population.

Fang Yu Y Zhang Lu L Zhou Gang-Qiao GQ Wang Zhi-Fu ZF Feng Kai K Lou Zhi-Yi ZY Pang Wei W Li Lei L Ling Yan Y Li Yu-Xia YX Liu Bao-Chi BC

World journal of emergency medicine 20100101 3

<h4>Background</h4>The tumor necrosis factor recepter associated factor (TRAF) 6 is an important intracellular adapter protein that plays a pivotal role in activating multiple inflammatory and immune related processes induced by cytokines. TRAF6 represents a strong candidate susceptibility factor for sepsis. We investigated whether polymorphisms at the TRAF6 gene are associated with the susceptibility to and severity of sepsis.<h4>Methods</h4>A hospital-based case-control study was conducted wit ...[more]

PMID: 25214962

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Project description:BACKGROUND:CD40, encoded by TNFRSF5, participates in the survival of B cells, process of antigen presentation and generation of CD8+ T cell memory. It also has an important effect on HCV antiviral immune response. This study aims to investigate whether TNFRSF5 gene polymorphisms are associated with HCV infection outcomes among Chinese population. METHODS:Three single nucleotide polymorphism (SNPs) (rs1535045, rs1883832, rs4810485) on TNFRSF5 were genotyped by TaqMan assay among Chinese population, including 1513 uninfected subjects, 496 spontaneous viral clearance subjects and 768 persistent HCV-infected subjects. Logistic analysis was used to compare these SNPs among different groups in this cross-sectional study. Functional annotations of the identified SNPs were further evaluated by bioinformatics analysis. RESULTS:After adjusted by age, gender and routes of infection, the results of logistic analysis indicated that individuals carrying rs1535045 T allele had a higher risk to infect HCV compared with C allele (in recessive model, adjusted OR?=?1.368, 95%CI?=?1.070-1.749, P?=?0.012). Subjects carried rs1535045 TT genotype were more likely to infect HCV than wild CC genotype (adjusted OR?=?1.397, 95%CI?=?1.078-1.809, P?=?0.011). For rs1883832, T allele was significantly associated with an increased risk of HCV infection (in recessive model, adjusted OR?=?1.337, 95%CI?=?1.069-1.673, P?=?0.011). Subjects with TT genotype had more possibility to infect HCV (adjusted OR?=?1.351, 95%CI?=?1.060-1.702, P?=?0.015). In the stratified analysis, rs1535045 and rs1883832 were remained in various subgroups and the heterogeneity test showed no pronounced heterogeneity in any pairwise comparison (all P?>?0.05). In addition, the results of the cumulative effects showed a tendency of that the more risk alleles (rs1535045 T and rs1883832 T) subjects carried, the more possibility of HCV infection exhibited (P<0.001). In haplotype analyses, compared with the CC haplotype, CT, TC and TT was correlated with an increased risk to infect HCV (P?=?0.029, P?=?0.047 and P<0.001, respectively). CONCLUSIONS:In conclusion, CD40 polymorphisms were significantly associated with the susceptibility to HCV among Chinese populations.

Dataset Information

TRAF6 polymorphisms not associated with the susceptibility to and severity of sepsis in a Chinese population.

Publications

TRAF6 polymorphisms not associated with the susceptibility to and severity of sepsis in a Chinese population.

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