Ontology highlight
ABSTRACT:
SUBMITTER: Villarreal DO
PROVIDER: S-EPMC4130175 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Villarreal Daniel O DO Wise Megan C MC Walters Jewell N JN Reuschel Emma L EL Choi Min Joung MJ Obeng-Adjei Nyamekye N Yan Jian J Morrow Matthew P MP Weiner David B DB
Cancer research 20140121 6
Studies of interleukin (IL)-33 reveal a number of pleiotropic properties. Here, we report that IL-33 has immunoadjuvant effects in a human papilloma virus (HPV)-associated model for cancer immunotherapy where cell-mediated immunity is critical for protection. Two biologically active isoforms of IL-33 exist that are full-length or mature, but the ability of either isoform to function as a vaccine adjuvant that influences CD4 T helper 1 or CD8 T-cell immune responses is not defined. We showed that ...[more]