Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen UT
PROVIDER: S-EPMC4130351 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Nguyen Uyen T T UT Bittova Lenka L Müller Manuel M MM Fierz Beat B David Yael Y Houck-Loomis Brian B Feng Vanessa V Dann Geoffrey P GP Muir Tom W TW
Nature methods 20140706 8
Elucidating the molecular details of how chromatin-associated factors deposit, remove and recognize histone post-translational modification (PTM) signatures remains a daunting task in the epigenetics field. We introduce a versatile platform that greatly accelerates biochemical investigations into chromatin recognition and signaling. This technology is based on the streamlined semisynthesis of DNA-barcoded nucleosome libraries with distinct combinations of PTMs. Chromatin immunoprecipitation of t ...[more]