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Identification of cancer stem cells and a strategy for their elimination.

ABSTRACT: It has been established previously that up to 40% of mouse CD34(+) hematopoietic stem cells are capable of internalizing exogenous dsDNA fragments both in vivo and ex vivo. Importantly, when mice are treated with a combination of cyclophosphamide and dsDNA, the repair of interstrand crosslinks in hematopoietic progenitors is attenuated, and their pluripotency is altered. Here we show for the first time that among various actively proliferating mammalian cell populations there are subpopulations capable of internalizing dsDNA fragments. In the context of cancer, such dsDNA-internalizing cell subpopulations display cancer stem cell-like phenotype. Furthermore, using Krebs-2 ascites cells as a model, we found that upon combined treatment with cyclophosphamide and dsDNA, engrafted material loses its tumor-initiating properties which we attribute to the elimination of tumor-initiating stem cell subpopulation or loss of its tumorigenic potential.

SUBMITTER: Dolgova EV

PROVIDER: S-EPMC4130731 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Identification of cancer stem cells and a strategy for their elimination.

Dolgova Evgenia V EV Alyamkina Ekaterina A EA Efremov Yaroslav R YR Nikolin Valeriy P VP Popova Nelly A NA Tyrinova Tamara V TV Kozel Artem V AV Minkevich Alexandra M AM Andrushkevich Oleg M OM Zavyalov Evgeniy L EL Romaschenko Alexander V AV Bayborodin Sergey I SI Taranov Oleg S OS Omigov Vladimir V VV Shevela Ekaterina Ya EY Stupak Vyacheslav V VV Mishinov Sergey V SV Rogachev Vladimir A VA Proskurina Anastasia S AS Mayorov Vladimir I VI Shurdov Mikhail A MA Ostanin Alexander A AA Chernykh Elena R ER Bogachev Sergey S SS

Cancer biology & therapy 20141001 10

It has been established previously that up to 40% of mouse CD34(+) hematopoietic stem cells are capable of internalizing exogenous dsDNA fragments both in vivo and ex vivo. Importantly, when mice are treated with a combination of cyclophosphamide and dsDNA, the repair of interstrand crosslinks in hematopoietic progenitors is attenuated, and their pluripotency is altered. Here we show for the first time that among various actively proliferating mammalian cell populations there are subpopulations ...[more]

PMID: 25117082

Dataset Information

Identification of cancer stem cells and a strategy for their elimination.

Publications

Identification of cancer stem cells and a strategy for their elimination.

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