Ontology highlight
ABSTRACT:
SUBMITTER: Salian-Mehta S
PROVIDER: S-EPMC4130768 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Salian-Mehta Smita S Xu Mei M Pierce Angela A Bliesner Brian B Tobet Stuart S Wierman Margaret E ME
Molecular and cellular endocrinology 20140627 1-2
Prior work has shown the importance of TAM (Tyro3, Axl, Mer) receptor tyrosine kinases in GnRH neuronal development and reproductive function. It is unclear if TAM receptor actions are dependent on ligand activation for their functional effects; thus, we characterized reproductive phenotype of ligand Growth arrest specific gene (Gas6) null mice. Gas6 null mice showed delayed vaginal opening and delayed first estrus. Animals eventually attained normal estrous cycles as adults. The GnRH neuronal p ...[more]