Ontology highlight
ABSTRACT:
SUBMITTER: Winston-McPherson GN
PROVIDER: S-EPMC4130779 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Winston-McPherson Gabrielle N GN Shu Dongxu D Tang Weiping W
Bioorganic & medicinal chemistry letters 20140618 16
Recent studies suggest that arylhydrocarbon receptor (AhR) may be a target for a number of diseases. Natural product malassezin is a AhR agonist with an interesting 2,3'-diindolylmethane skeleton. We have prepared a series of analogues of natural product malassezin using our recently developed method and tested the activity of these analogues against AhR in a cell-based assay. We found that a methyl substituent at 1'-N can significantly increase the activity and the 2-formyl group is not critica ...[more]