Ontology highlight
ABSTRACT:
SUBMITTER: Yim PD
PROVIDER: S-EPMC4131261 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Yim Peter D PD Gallos George G Perez-Zoghbi Jose F JF Trice Jacquelyn J Zhang Yi Y Siviski Matthew M Sonett Joshua J Emala Charles W CW
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20130101
Enhanced airway smooth muscle (ASM) contraction is an important component in the pathophysiology of asthma. We have shown that ligand gated chloride channels modulate ASM contractile tone during the maintenance phase of an induced contraction, however the role of chloride flux in depolarization-induced contraction remains incompletely understood. To better understand the role of chloride flux under these conditions, muscle force (human ASM, guinea pig ASM), peripheral small airway luminal area ( ...[more]