Genetic contribution to postpartum haemorrhage in Swedish population: cohort study of 466,686 births.

ABSTRACT:

Objective

To investigate the familial clustering of postpartum haemorrhage in the Swedish population, and to quantify the relative contributions of genetic and environmental effects.

Design

Register based cohort study.

Setting

Swedish population (multi-generation and medical birth registers).

Main outcome measure

Postpartum haemorrhage, defined as >1000 mL estimated blood loss.

Participants

The first two live births to individuals in Sweden in 1997-2009 contributed to clusters representing intact couples (n = 366,350 births), mothers with separate partners (n = 53,292), fathers with separate partners (n = 47,054), sister pairs (n = 97,228), brother pairs (n = 91,168), and mixed sibling pairs (n = 177,944).

Methods

Familial clustering was quantifie

SUBMITTER: Oberg AS 

PROVIDER: S-EPMC4131501 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature