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Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity


ABSTRACT: Three new sesquilignans, 1–3, a new sesquiterpenoid, 4, and three known compounds were isolated from the stem barks of Illicium simonsii. The structures of new compounds (1–4) were elucidated by spectroscopic methods. A biosynthetic pathway was proposed for simonsienols A-C (1–3). Anti-AChE activity and anti-BuChE activity were evaluated for all compounds except for α-cadinol ethyl ether (4). As a result, isodunnianol (7) exhibited anti-AChE activity with an IC50 value of 13.0 µM.

Electronic Supplementary Material

Supplementary material is available for this article at 10.1007/s13659-012-0026-z and is accessible for authorized users.

SUBMITTER: Dong C 

PROVIDER: S-EPMC4131593 | biostudies-literature |

REPOSITORIES: biostudies-literature

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