Chemical constituents from the aerial parts of Euphorbia sikkimensis and their bioactivities
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ABSTRACT: Phytochemical investigation of the aerial parts of Euphorbia sikkimensis led to the isolation of one new diterpenoids, named sikkimenoid E (1), together with thirteen other known compounds (2–14). Their structures were established by means of spectroscopic methods. Compound 2 was identified to be a trinortriterpenoid, and derived for the first time from a natural source. In this paper we reveal for the first time its comprehensive spectral data and NMR spectral assignment. Compound 4 showed antiangiogenic activity with an IC50 value of 5.66 µM in a zebrafish model, and compounds 5 and 6 exhibited cytotoxicity toward A549 cell line with IC50 values of 12.12 and 6.45 µM, respectively. Electronic Supplementary Material
Supplementary material is available for this article at 10.1007/s13659-013-0006-y and is accessible for authorized users.
SUBMITTER: Yang D
PROVIDER: S-EPMC4131670 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
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