Ontology highlight
ABSTRACT:
SUBMITTER: Onoda A
PROVIDER: S-EPMC4132749 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Onoda Akihisa A Hosoya Osamu O Sano Kuniaki K Kiyama Kazuko K Kimura Hiroshi H Kawano Shinji S Furuta Ryohei R Miyaji Mary M Tsutsui Ken K Tsutsui Kimiko M KM
Nucleic acids research 20140717 14
DNA topoisomerase II (topo II) changes DNA topology by cleavage/re-ligation cycle(s) and thus contributes to various nuclear DNA transactions. It is largely unknown how the enzyme is controlled in a nuclear context. Several studies have suggested that its C-terminal domain (CTD), which is dispensable for basal relaxation activity, has some regulatory influence. In this work, we examined the impact of nuclear localization on regulation of activity in nuclei. Specifically, human cells were transfe ...[more]