Ontology highlight
ABSTRACT:
SUBMITTER: Edwards W
PROVIDER: S-EPMC4132777 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20140617 33
Ion channels are an attractive class of drug targets, but progress in developing inhibitors for therapeutic use has been limited largely due to challenges in identifying subtype selective small molecules. Animal venoms provide an alternative source of ion channel modulators, and the venoms of several species, such as scorpions, spiders and snails, are known to be rich sources of ion channel modulating peptides. Importantly, these peptides often bind to hyper-variable extracellular loops, creatin ...[more]