Circulating Ki-67 protein in plasma as a biomarker and prognostic indicator of acute lymphoblastic leukemia.
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ABSTRACT:
SUBMITTER: Bruey JM
PROVIDER: S-EPMC4132892 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Circulating Ki-67 protein in plasma as a biomarker and prognostic indicator of acute lymphoblastic leukemia.
Bruey Jean-Marie JM Kantarjian Hagop H Estrov Zeev Z Zhang Zhong Z Ma Wanlong W Albitar Ferras F Abdool Adam A Thomas Deborah D Yeh Chenhsiung C O'Brien Susan S Albitar Maher M
Leukemia research 20090812 2
Tissue-based determination of Ki-67, a marker of cellular proliferation, has shown prognostic value in solid tumors and hematological malignancies. We developed and validated an electrochemiluminescence-based method for sensitive measurement of circulating Ki-67 in plasma (cKi-67). This assay demonstrated significantly higher levels of cKi-67 in patients with newly diagnosed acute lymphoblastic leukemia (ALL) (n=27; median, 762; range, 0-4574U/100 microL) than in healthy control subjects (n=114; ...[more]
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