Ontology highlight
ABSTRACT:
SUBMITTER: Florian S
PROVIDER: S-EPMC4132893 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Florian Simone S Krehl Susanne S Loewinger Maria M Kipp Anna A Banning Antje A Esworthy Steven S Chu Fong-Fong FF Brigelius-Flohé Regina R
Free radical biology & medicine 20100907 11
Localization of glutathione peroxidase 2 (GPx2), the gastrointestinal form of GPx's, in the intestinal crypt epithelium points to a specific but so-far unknown function of this particular GPx. Therefore, the consequences of a GPx2 knockout were tested in mice fed a selenium-restricted, Se-adequate, or Se-supplemented diet. An unexpected increase in total GPx activity was found throughout the intestine in selenium-fed GPx2 knockout (KO) animals. Immunohistochemistry revealed a strong increase in ...[more]