Ontology highlight
ABSTRACT:
SUBMITTER: Chan KK
PROVIDER: S-EPMC4133157 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Chan Kevin Ka Ming KK Seetharaman Ashwin A Bagg Rachel R Selman Guillermo G Zhang Yuqian Y Kim Joowan J Roy Peter J PJ
PLoS genetics 20140814 8
We recently discovered a secreted and diffusible midline cue called MADD-4 (an ADAMTSL) that guides migrations along the dorsoventral axis of the nematode Caenorhabditis elegans. We showed that the transmembrane receptor, UNC-40 (DCC), whose canonical ligand is the UNC-6 (netrin) guidance cue, is required for extension towards MADD-4. Here, we demonstrate that MADD-4 interacts with an EVA-1/UNC-40 co-receptor complex to attract cell extensions. EVA-1 is a conserved transmembrane protein with pre ...[more]