Model study of the pressure build-up during subcutaneous injection.
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ABSTRACT:
SUBMITTER: Thomsen M
PROVIDER: S-EPMC4133188 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Model study of the pressure build-up during subcutaneous injection.
Thomsen Maria M Hernandez-Garcia Anier A Mathiesen Joachim J Poulsen Mette M Sørensen Dan N DN Tarnow Lise L Feidenhans'l Robert R
PloS one 20140814 8
In this study we estimate the subcutaneous tissue counter pressure during drug infusion from a series of injections of insulin in type 2 diabetic patients using a non-invasive method. We construct a model for the pressure evolution in subcutaneous tissue based on mass continuity and the flow laws of a porous medium. For equivalent injection forces we measure the change in the infusion rate between injections in air at atmospheric pressure and in tissue. From a best fit with our model, we then de ...[more]
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