Ontology highlight
ABSTRACT:
SUBMITTER: Kier BL
PROVIDER: S-EPMC4133282 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Journal of peptide science : an official publication of the European Peptide Society 20140606 9
An extensive series of covalently linked small molecule-peptide adducts based on a terminally capped-beta hairpin motif is reported. The constructs can be prepared by standard solid-phase Fmoc chemistry with one to four peptide chains linked to small molecule hubs bearing carboxylic acid moieties. The key feature of interest is the precise, buried environment of the small molecule, and its rigid orientation relative to one or more short but fully structured peptide chain(s). Most of this study e ...[more]