Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC4133483 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Wang Lili L Shalek Alex K AK Lawrence Mike M Ding Ruihua R Gaublomme Jellert T JT Pochet Nathalie N Stojanov Petar P Sougnez Carrie C Shukla Sachet A SA Stevenson Kristen E KE Zhang Wandi W Wong Jessica J Sievers Quinlan L QL MacDonald Bryan T BT Vartanov Alexander R AR Goldstein Natalie R NR Neuberg Donna D He Xi X Lander Eric E Hacohen Nir N Regev Aviv A Getz Gad G Brown Jennifer R JR Park Hongkun H Wu Catherine J CJ
Blood 20140428 7
One major goal of cancer genome sequencing is to identify key genes and pathways that drive tumor pathogenesis. Although many studies have identified candidate driver genes based on recurrence of mutations in individual genes, subsets of genes with nonrecurrent mutations may also be defined as putative drivers if they affect a single biological pathway. In this fashion, we previously identified Wnt signaling as significantly mutated through large-scale massively parallel DNA sequencing of chroni ...[more]