Nature's recipe for splitting inteins.
Ontology highlight
ABSTRACT:
SUBMITTER: Aranko AS
PROVIDER: S-EPMC4133565 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Nature's recipe for splitting inteins.
Aranko A Sesilja AS Wlodawer Alexander A Iwaï Hideo H
Protein engineering, design & selection : PEDS 20140801 8
Protein splicing in trans by split inteins has increasingly become a powerful protein-engineering tool for protein ligation, both in vivo and in vitro. Over 100 naturally occurring and artificially engineered split inteins have been reported for protein ligation using protein trans-splicing. Here, we review the current status of the reported split inteins in order to delineate an empirical or rational strategy for constructing new split inteins suitable for various applications in biotechnology ...[more]
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