Genetic alterations of chromosome 8 genes in oral cancer.
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ABSTRACT:
SUBMITTER: Yong ZW
PROVIDER: S-EPMC4133705 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Genetic alterations of chromosome 8 genes in oral cancer.
Yong Zachary Wei Ern ZW Zaini Zuraiza Mohamad ZM Kallarakkal Thomas George TG Karen-Ng Lee Peng LP Rahman Zainal Ariff Abdul ZA Ismail Siti Mazlipah SM Sharifah Noor Akmal NA Mustafa Wan Mahadzir Wan WM Abraham Mannil Thomas MT Tay Keng Kiong KK Zain Rosnah Binti RB
Scientific reports 20140815
The clinical relevance of DNA copy number alterations in chromosome 8 were investigated in oral cancers. The copy numbers of 30 selected genes in 33 OSCC patients were detected using the multiplex ligation-dependent probe amplification (MLPA) technique. Amplifications of the EIF3E gene were found in 27.3% of the patients, MYC in 18.2%, RECQL4 in 15.2% and MYBL1 in 12.1% of patients. The most frequent gene losses found were the GATA4 gene (24.2%), FGFR1 gene (24.2%), MSRA (21.2) and CSGALNACT1 (1 ...[more]
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