Ontology highlight
ABSTRACT:
SUBMITTER: Park JM
PROVIDER: S-EPMC4133879 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Park Ji-Min JM Ho Dong-Hwan DH Yun Hye Jin HJ Kim Hye-Jung HJ Lee Chan Hong CH Park Sung Woo SW Kim Young Hoon YH Son Ilhong I Seol Wongi W
BMB reports 20130901 9
LRRK2 (leucine-rich repeat kinase 2) has been identified as a gene corresponding to PARK8, an autosomal-dominant gene for familial Parkinson's disease (PD). LRRK2 pathogenic-specific mutants induce neurotoxicity and shorten neurites. To elucidate the mechanism underlying LRRK2 expression, we constructed the LRRK2-promoter-luciferase reporter and used it for promoter analysis. We found that the glucocorticoid receptor (GR) transactivated LRRK2 in a ligand-dependent manner. Using quantitative RT-P ...[more]