Regulation of articular chondrocyte aggrecan and collagen gene expression by multiple growth factor gene transfer.

ABSTRACT: Gene transfer is a promising approach to the delivery of chondrotrophic growth factors to promote cartilage repair. It is unlikely that a single growth factor transgene will optimally regulate these cells. The aim of this study was to identify those growth factor transgene combinations that optimally regulate aggrecan, collagen type II and collagen type I gene expression by articular chondrocytes. We delivered combinations of the transgenes encoding fibroblast growth factor-2, insulin-like growth factor I, transforming growth factor beta1, bone morphogenetic protein-2, and/or bone morphogenetic protein-7 and assessed chondrocyte responses by measuring changes in the expression of aggrecan, type II collagen and type I collagen genes. These growth factor transgenes differentially regulated t

SUBMITTER: Shi S 

PROVIDER: S-EPMC4133938 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature