Ontology highlight
ABSTRACT:
SUBMITTER: Cronin RM
PROVIDER: S-EPMC4134007 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Cronin Robert M RM Field Julie R JR Bradford Yuki Y Shaffer Christian M CM Carroll Robert J RJ Mosley Jonathan D JD Bastarache Lisa L Edwards Todd L TL Hebbring Scott J SJ Lin Simon S Hindorff Lucia A LA Crane Paul K PK Pendergrass Sarah A SA Ritchie Marylyn D MD Crawford Dana C DC Pathak Jyotishman J Bielinski Suzette J SJ Carrell David S DS Crosslin David R DR Ledbetter David H DH Carey David J DJ Tromp Gerard G Williams Marc S MS Larson Eric B EB Jarvik Gail P GP Peissig Peggy L PL Brilliant Murray H MH McCarty Catherine A CA Chute Christopher G CG Kullo Iftikhar J IJ Bottinger Erwin E Chisholm Rex R Smith Maureen E ME Roden Dan M DM Denny Joshua C JC
Frontiers in genetics 20140805
Phenome-wide association studies (PheWAS) have demonstrated utility in validating genetic associations derived from traditional genetic studies as well as identifying novel genetic associations. Here we used an electronic health record (EHR)-based PheWAS to explore pleiotropy of genetic variants in the fat mass and obesity associated gene (FTO), some of which have been previously associated with obesity and type 2 diabetes (T2D). We used a population of 10,487 individuals of European ancestry wi ...[more]