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Dengue virus 2 American-Asian genotype identified during the 2006/2007 outbreak in Piaui, Brazil reveals a Caribbean route of introduction and dissemination of dengue virus in Brazil.


ABSTRACT: Dengue virus (DENV) is the most widespread arthropod-borne virus, and the number and severity of outbreaks has increased worldwide in recent decades. Dengue is caused by DENV-1, DENV- 2, DENV-3 and DENV-4 which are genetically distant. The species has been subdivided into genotypes based on phylogenetic studies. DENV-2, which was isolated from dengue fever patients during an outbreak in Piaui, Brazil in 2006/2007 was analyzed by sequencing the envelope (E) gene. The results indicated a high similarity among the isolated viruses, as well as to other DENV-2 from Brazil, Central America and South America. A phylogenetic and phylogeographic analysis based on DENV-2E gene sequences revealed that these viruses are grouped together with viruses of the American-Asian genotype in two distinct lineages. Our results demonstrate the co-circulation of two American-Asian genotype lineages in northeast Brazil. Moreover, we reveal that DENV-2 lineage 2 was detected in Piauí before it disseminated to other Brazilian states and South American countries, indicating the existence of a new dissemination route that has not been previously described.

SUBMITTER: Barcelos Figueiredo L 

PROVIDER: S-EPMC4134198 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Dengue virus 2 American-Asian genotype identified during the 2006/2007 outbreak in Piauí, Brazil reveals a Caribbean route of introduction and dissemination of dengue virus in Brazil.

Barcelos Figueiredo Leandra L   Sakamoto Tetsu T   Leomil Coelho Luiz Felipe LF   de Oliveira Rocha Eliseu Soares ES   Gomes Cota Marcela Menezes MM   Ferreira Gustavo Portela GP   de Oliveira Jaquelline Germano JG   Kroon Erna Geessien EG  

PloS one 20140815 8


Dengue virus (DENV) is the most widespread arthropod-borne virus, and the number and severity of outbreaks has increased worldwide in recent decades. Dengue is caused by DENV-1, DENV- 2, DENV-3 and DENV-4 which are genetically distant. The species has been subdivided into genotypes based on phylogenetic studies. DENV-2, which was isolated from dengue fever patients during an outbreak in Piaui, Brazil in 2006/2007 was analyzed by sequencing the envelope (E) gene. The results indicated a high simi  ...[more]

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