Ontology highlight
ABSTRACT:
SUBMITTER: Pan XN
PROVIDER: S-EPMC4134294 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Pan Xiao-Na XN Chen Jia-Jie JJ Wang Le-Xun LX Xiao Ruo-Zhi RZ Liu Ling-Ling LL Fang Zhi-Gang ZG Liu Quentin Q Long Zi-Jie ZJ Lin Dong-Jun DJ
PloS one 20140815 8
Nowadays, drug resistance still represents a major obstacle to successful acute myeloid leukemia (AML) treatment and the underlying mechanism is not fully elucidated. Here, we found that high expression of c-Myc was one of the cytogenetic characteristics in the drug-resistant leukemic cells. c-Myc over-expression in leukemic cells induced resistance to chemotherapeutic drugs, enhanced colony formation capacity and inhibited cell differentiation induced by all-trans retinoic acid (ATRA). Meanwhil ...[more]