Ontology highlight
ABSTRACT:
SUBMITTER: Huerta-Sanchez E
PROVIDER: S-EPMC4134395 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Huerta-Sánchez Emilia E Jin Xin X Asan Bianba Zhuoma Z Peter Benjamin M BM Vinckenbosch Nicolas N Liang Yu Y Yi Xin X He Mingze M Somel Mehmet M Ni Peixiang P Wang Bo B Ou Xiaohua X Huasang Luosang Jiangbai J Cuo Zha Xi Ping ZX Li Kui K Gao Guoyi G Yin Ye Y Wang Wei W Zhang Xiuqing X Xu Xun X Yang Huanming H Li Yingrui Y Wang Jian J Wang Jun J Nielsen Rasmus R
Nature 20140702 7513
As modern humans migrated out of Africa, they encountered many new environmental conditions, including greater temperature extremes, different pathogens and higher altitudes. These diverse environments are likely to have acted as agents of natural selection and to have led to local adaptations. One of the most celebrated examples in humans is the adaptation of Tibetans to the hypoxic environment of the high-altitude Tibetan plateau. A hypoxia pathway gene, EPAS1, was previously identified as hav ...[more]