A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer.

ABSTRACT:

Purpose

Krüppel-like factor 4 (KLF4) is a transcription factor and putative tumor suppressor. However, little is known about its effect on aerobic glycolysis in pancreatic tumors. Therefore, we investigated the clinical significance, biologic effects, and mechanisms of dysregulated KLF4 signaling in aerobic glycolysis in pancreatic cancer cells.

Experimental design

Expression of KLF4 and lactate dehydrogenase A (LDHA) in 70 primary pancreatic tumors and 10 normal pancreatic tissue specimens was measured. Also, the underlying mechanisms of altered KLF4 expression and its impact on aerobic glycolysis in pancreatic cancer cells were investigated.

Results

We found a negative correlation between KLF4 and LDHA expression in pancreatic cancer cells and tissues and that their

SUBMITTER: Shi M 

PROVIDER: S-EPMC4134726 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature