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Genome reactivation after the silence in mitosis: recapitulating mechanisms of development?

ABSTRACT: Transcription is silenced during mitosis and reactivated at mitotic exit. The dynamics and identities of "bookmarking" transcription factors and chromatin marks that mediate reactivation often recapitulate those observed during cell identity establishment in development. Thus, features of postmitotic gene reactivation can provide insights into mechanisms of developmental cell fate establishment.

SUBMITTER: Zaret KS

PROVIDER: S-EPMC4134911 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Genome reactivation after the silence in mitosis: recapitulating mechanisms of development?

Zaret Kenneth S KS

Developmental cell 20140401 2

Transcription is silenced during mitosis and reactivated at mitotic exit. The dynamics and identities of "bookmarking" transcription factors and chromatin marks that mediate reactivation often recapitulate those observed during cell identity establishment in development. Thus, features of postmitotic gene reactivation can provide insights into mechanisms of developmental cell fate establishment. ...[more]

PMID: 24780732

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