Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC4134939 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Journal of biomolecular NMR 20140501 2
Unambiguous detection and assignment of intermolecular NOEs are essential for structure determination of protein complexes by NMR. Such information has traditionally been obtained with 3-D half-filtered experiments, where scalar coupling-based purging of intramolecular signals allows for selective detection of intermolecular NOEs. However, due to the large variation of (1)JHC scalar couplings and limited chemical shift dispersion in the indirect proton dimension, it is difficult to obtain reliab ...[more]