A review of selected candidate endophenotypes for depression.
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ABSTRACT:
SUBMITTER: Goldstein BL
PROVIDER: S-EPMC4134952 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
A review of selected candidate endophenotypes for depression.
Goldstein Brandon L BL Klein Daniel N DN
Clinical psychology review 20140619 5
Endophenotypes are proposed to occupy an intermediate position in the pathway between genotype and phenotype in genetically complex disorders such as depression. To be considered an endophenotype, a construct must meet a set of criteria proposed by Gottesman and Gould (2003). In this qualitative review, we summarize evidence for each criterion for several putative endophenotypes for depression: neuroticism, morning cortisol, frontal asymmetry of cortical electrical activity, reward learning, and ...[more]
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